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               SU11248 evaluated in vivo by dynamic contrast-enhanced magnetic resonance imaging in an
               experimental model of colon carcinoma. Clin Cancer Res 11:5827–5832
              60. Tabernero J (2007) The role of VEGF and EGFR inhibition: implications for combining
               anti-VEGF and anti-EGFR agents. Mol Cancer Res 5:203–220
              61. Frost P, Moatamed F, Hoang B, Shi Y, Gera J, Yan H, Frost P, Gibbons J, Lichtenstein A
               (2004) In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple
               myeloma cells in a xenograft model. Blood 104:4181–4187
              62. Sunwoo JB, Chen Z, Dong G, Yeh N, Crowl Bancroft C, Sausville E, Adams J, Elliott P, Van
               Waes  C  (2001)  Novel  proteasome  inhibitor  PS-341  inhibits  activation  of  nuclear  factor-
               kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. Clin
               Cancer Res 7:1419–1428
              63. Melchert M, List A (2007) The thalidomide saga. Int J Biochem Cell Biol 39:1489–1499
              64. Teicher BA, Sotomayor EA, Huang ZD (1992) Antiangiogenic agents potentiate cytotoxic
               cancer therapies against primary and metastatic disease. Cancer Res 52:6702–6704
              65. Kakeji Y, Teicher BA (1997) Preclinical studies of the combination of angiogenic inhibitors
               with cytotoxic agents. Invest New Drugs 15:39–48
              66. Miller KD, Sweeney CJ, Sledge GW Jr (2001) Redefining the target: chemotherapeutics as
               antiangiogenics. J Clin Oncol 19:1195–1206
              67. Merke  J,  Milde  P,  Lewicka  S,  Hugel  U,  Klaus  G,  Mangelsdorf  DJ,  Haussler  MR,
               Rauterberg EW, Ritz E (1989) Identification and regulation of 1, 25-dihydroxyvitamin D3
               receptor  activity  and  biosynthesis  of  1,  25-dihydroxyvitamin  D3.  Studies  in  cultured
               bovine aortic endothelial cells and human dermal capillaries. J Clin Invest 83:1903–1915
              68. Bernardi RJ, Johnson CS, Modzelewski RA, Trump DL (2002) Antiproliferative effects of
               1alpha,  25-dihydroxyvitamin  D(3)  and  vitamin  D  analogs  on  tumor-derived  endothelial
               cells. Endocrinology 143:2508–2514
              69. Chung I, Wong MK, Flynn G, Yu WD, Johnson CS, Trump DL (2006) Differential antipro-
               liferative effects of calcitriol on tumor-derived and matrigel-derived endothelial cells. Cancer
               Res 66:8565–8573
              70. Merke J, Hofmann W, Goldschmidt D, Ritz E (1987) Demonstration of 1, 25(OH)2 vitamin D3
               receptors and actions in vascular smooth muscle cells in vitro. Calcif Tissue Int 41:112–114
              71. Koh E, Morimoto S, Fukuo K, Itoh K, Hironaka T, Shiraishi T, Onishi T, Kumahara Y (1988)
               1, 25-Dihydroxyvitamin D3 binds specifically to rat vascular smooth muscle cells and stimu-
               lates their proliferation in vitro. Life Sci 42:215–223
              72. Mitsuhashi T, Morris RC Jr, Ives HE (1991) 1, 25-dihydroxyvitamin D3 modulates growth
               of vascular smooth muscle cells. J Clin Invest 87:1889–1895
              73. Cardus  A,  Parisi  E,  Gallego  C,  Aldea  M,  Fernandez  E,  Valdivielso  JM  (2006)  1,
               25-Dihydroxyvitamin  D3  stimulates  vascular  smooth  muscle  cell  proliferation  through  a
               VEGF-mediated pathway. Kidney Int 69:1377–1384
              74. Rajasree S, Umashankar PR, Lal AV, Sarma PS, Kartha CC (2002) 1, 25-dihydroxyvitamin
               D3 receptor is upregulated in aortic smooth muscle cells during hypervitaminosis D. Life Sci
               70:1777–1788
              75. Zehnder  D,  Bland  R,  Chana  RS,  Wheeler  DC,  Howie  AJ,  Williams  MC,  Stewart  PM,
               Hewison M (2002) Synthesis of 1, 25-dihydroxyvitamin D(3) by human endothelial cells is
               regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhe-
               sion. J Am Soc Nephrol 13:621–629
              76. Mantell  DJ,  Owen  PE,  Bundred  NJ,  Mawer  EB,  Canfield  AE  (2000)  1  alpha,
               25- dihydroxyvitamin D(3) inhibits angiogenesis in vitro and in vivo. Circ Res 87:214–220
              77. Albert DM, Scheef EA, Wang S, Mehraein F, Darjatmoko SR, Sorenson CM, Sheibani N
               (2007) Calcitriol is a potent inhibitor of retinal neovascularization. Invest Ophthalmol Vis
               Sci 48:2327–2334
              78. Chung I, Karpf AR, Muindi JR, Conroy JM, Nowak NJ, Johnson CS, Trump DL (2007)
               Epigenetic silencing of CYP24 in tumor-derived endothelial cells contributes to selective
               growth inhibition by calcitriol. J Biol Chem 282:8704–8714
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