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7 Induction of Differentiation in Cancer Cells by Vitamin D 169

101. Manggau M, Kim DS, Ruwisch L, Vogler R, Korting HC, Schafer-Korting M, Kleuser
B (2001) 1alpha, 25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by
the formation of sphingosine-1-phosphate. J Invest Dermatol 117:1241–1249
102. Lu J, Goldstein KM, Chen P, Huang S, Gelbert LM, Nagpal S (2005) Transcriptional profiling
of keratinocytes reveals a vitamin D-regulated epidermal differentiation network. J Invest
Dermatol 124:778–785
103. Feinberg MW, Wara AK, Cao Z, Lebedeva MA, Rosenbauer F, Iwasaki H, Hirai H, Katz JP,
Haspel RL, Gray S, Akashi K, Segre J, Kaestner KH, Tenen DG, Jain MK (2007) The Kruppel-
like factor KLF4 is a critical regulator of monocyte differentiation. Embo J 26:4138–4148
104. Autieri MV (2008) Kruppel-like factor 4: transcriptional regulator of proliferation, or
inflammation, or differentiation, or all three? Circ Res 102:1455–1457
105. Alder JK, Georgantas RW 3rd, Hildreth RL, Kaplan IM, Morisot S, Yu X, McDevitt M,
Civin CI (2008) Kruppel-like factor 4 is essential for inflammatory monocyte differentiation
in vivo. J Immunol 180:5645–5652
106. Dai X, Sayama K, Shirakata Y, Tokumaru S, Yang L, Tohyama M, Hirakawa S, Hanakawa Y,
Hashimoto K (2008) PPAR gamma is an important transcription factor in 1 alpha, 25-dihy-
droxyvitamin D3-induced involucrin expression. J Dermatol Sci 50:53–60
107. Bikle DD, Pillai S, Gee E (1991) Squamous carcinoma cell lines produce 1, 25 dihydroxyvi-
tamin D, but fail to respond to its prodifferentiating effect. J Invest Dermatol 97:435–441
108. Solomon C, White JH, Kremer R (1999) Mitogen-activated protein kinase inhibits 1,
25-dihydroxyvitamin D3-dependent signal transduction by phosphorylating human retinoid
X receptor alpha. J Clin Invest 103:1729–1735
109. McGuire TF, Trump DL, Johnson CS (2001) Vitamin D3-induced apoptosis of murine
squamous cell carcinoma cells. Selective induction of caspase-dependent MEK cleavage and
up-regulation of MEKK-1. J Biol Chem 276:26365–26373
110. Ma Y, Yu WD, Kong RX, Trump DL, Johnson CS (2006) Role of nongenomic activation of
phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase/extracellular signal-
regulated kinase kinase/extracellular signal-regulated kinase 1/2 pathways in 1,25D3-medi-
ated apoptosis in squamous cell carcinoma cells. Cancer Res 66:8131–8138
111. Xie Z, Bikle DD (1998) Differential regulation of vitamin D responsive elements in normal
and transformed keratinocytes. J Invest Dermatol 110:730–733
112. Goltzman D, White J, Kremer R (2001) Studies of the effects of 1, 25-dihydroxyvitamin D
on skeletal and calcium homeostasis and on inhibition of tumor cell growth. J Steroid
Biochem Mol Biol 76:43–47
113. Oda Y, Sihlbom C, Chalkley RJ, Huang L, Rachez C, Chang CP, Burlingame AL, Freedman
LP, Bikle DD (2003) Two distinct coactivators, DRIP/mediator and SRC/p160, are differen-
tially involved in vitamin D receptor transactivation during keratinocyte differentiation. Mol
Endocrinol 17:2329–2339
114. Tokuumi Y (1995) Correlation between the concentration of 1, 25 alpha dihydroxyvitamin
D3 receptors and growth inhibition, and differentiation of human osteosarcoma cells induced
by vitamin D3. Nippon Seikeigeka Gakkai Zasshi 69:181–190
115. Van Auken M, Buckley D, Ray R, Holick MF, Baran DT (1996) Effects of the vitamin D3
analog 1 alpha, 25-dihydroxyvitamin D3–3 beta-bromoacetate on rat osteosarcoma cells:
comparison with 1 alpha, 25-dihydroxyvitamin D3. J Cell Biochem 63:302–310
116. Harris SA, Enger RJ, Riggs BL, Spelsberg TC (1995) Development and characterization of a
conditionally immortalized human fetal osteoblastic cell line. J Bone Miner Res 10:178–86
117. Vertino AM, Bula CM, Chen JR, Almeida M, Han L, Bellido T, Kousteni S, Norman AW,
Manolagas SC (2005) Nongenotropic, anti-apoptotic signaling of 1alpha, 25(OH) -vitamin
2
D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts
and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases. J Biol Chem
280:14130–14137
118. Cordero JB, Cozzolino M, Lu Y, Vidal M, Slatopolsky E, Stahl PD, Barbieri MA, Dusso A
(2002) 1, 25-Dihydroxyvitamin D down-regulates cell membrane growth- and nuclear growth-
promoting signals by the epidermal growth factor receptor. J Biol Chem 277:38965–38971