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7 Induction of Differentiation in Cancer Cells by Vitamin D 171

137. Hewison M, Dabrowski M, Vadher S, Faulkner L, Cockerill FJ, Brickell PM, ÓRiordan JL,
Katz DR (1996) Antisense inhibition of vitamin D receptor expression induces apoptosis in
monoblastoid U937 cells. J Immunol 156:4391–4400
138. Marcinkowska E, Chrobak A, Wiedlocha A (2001) Evading apoptosis by calcitriol-dif-
ferentiated human leukemic HL-60 cells is not mediated by changes in CD95 receptor
system but by increased sensitivity of these cells to insulin. Exp Cell Res 270:119–127
139. Zhang Y, Zhang J, Studzinski GP (2006) AKT pathway is activated by 1, 25-dihydroxyvita-
min D3 and participates in its anti-apoptotic effect and cell cycle control in differentiating
HL60 cells. Cell Cycle 5:447–451
140. Wang X, Studzinski GP (2006) The requirement for and changing composition of the activating
protein-1 transcription factor during differentiation of human leukemia HL60 cells induced
by 1, 25-dihydroxyvitamin D3. Cancer Res 66:4402–4409
141. Nakagawa K, Kurobe M, Konno K, Fujishima T, Takayama H, Okano T (2000) Structure-
specific control of differentiation and apoptosis of human promyelocytic leukemia (HL-60)
cells by A-ring diastereomers of 2-methyl-1alpha, 25-dihydroxyvitamin D3 and its
20-epimer. Biochem Pharmacol 60:1937–1947
142. Urahama N, Ito M, Sada A, Yakushijin K, Yamamoto K, Okamura A, Minagawa K, Hato A,
Chihara K, Roeder RG, Matsui T (2005) The role of transcriptional coactivator TRAP220 in
myelomonocytic differentiation. Genes Cells 10:1127–1137
143. Ikezoe T, Bandobashi K, Yang Y, Takeuchi S, Sekiguchi N, Sakai S, Koeffler HP, Taguchi H
(2006) HIV-1 protease inhibitor ritonavir potentiates the effect of 1, 25-dihydroxyvitamin D3
to induce growth arrest and differentiation of human myeloid leukemia cells via down-
regulation of CYP24. Leuk Res 30:1005–1011
144. Takahashi E, Nakagawa K, Suhara Y, Kittaka A, Nihei K, Konno K, Takayama H, Ozono K,
Okano T (2006) Biological activities of 2alpha-substituted analogues of 1alpha, 25-dihy-
droxyvitamin D3 in transcriptional regulation and human promyelocytic leukemia (HL-60)
cell proliferation and differentiation. Biol Pharm Bull 29:2246–2250
145. Suzuki T, Tazoe H, Taguchi K, Koyama Y, Ichikawa H, Hayakawa S, Munakata H, Isemura
M (2006) DNA microarray analysis of changes in gene expression induced by 1, 25-dihy-
droxyvitamin D3 in human promyelocytic leukemia HL-60 cells. Biomed Res 27:99–109
146. Hughes PJ, Brown G (2006) 1Alpha, 25-dihydroxyvitamin D3-mediated stimulation of ste-
roid sulphatase activity in myeloid leukaemic cell lines requires VDRnuc-mediated activa-
tion of the RAS/RAF/ERK-MAP kinase signalling pathway. J Cell Biochem 98:590–617
147. Hughes PJ, Lee JS, Reiner NE, Brown G (2008) The vitamin D receptor-mediated activation
of phosphatidylinositol 3-kinase (PI3Kalpha) plays a role in the 1alpha, 25-dihydroxyvitamin
D3-stimulated increase in steroid sulphatase activity in myeloid leukaemic cell lines. J Cell
Biochem 103:1551–1572
148. Munker R, Kobayashi T, Elstner E, Norman AW, Uskokovic M, Zhang W, Andreeff M,
Koeffler HP (1996) A new series of vitamin D analogs is highly active for clonal inhibition,
differentiation, and induction of WAF1 in myeloid leukemia. Blood 88:2201–2209
149. Muto A, Kizaki M, Yamato K, Kawai Y, Kamata-Matsushita M, Ueno H, Ohguchi M,
Nishihara T, Koeffler HP, Ikeda Y (1999) 1, 25-Dihydroxyvitamin D3 induces differentiation
of a retinoic acid-resistant acute promyelocytic leukemia cell line (UF-1) associated with
expression of p21(WAF1/CIP1) and p27(KIP1). Blood 93:2225–2233
150. Shiohara M, Uskokovic M, Hisatake J, Hisatake Y, Koike K, Komiyama A, Koeffler HP
(2001) 24-Oxo metabolites of vitamin D3 analogues: disassociation of their prominent anti-
leukemic effects from their lack of calcium modulation. Cancer Res 61:3361–3368
151. ÓKelly J, Uskokovic M, Lemp N, Vadgama J, Koeffler HP (2006) Novel Gemini-vitamin D3
analog inhibits tumor cell growth and modulates the Akt/mTOR signaling pathway. J Steroid
Biochem Mol Biol 100:107–16
152. Wang X, Studzinski GP (2001) Activation of extracellular signal-regulated kinases (ERKs)
defines the first phase of 1, 25-dihydroxyvitamin D3-induced differentiation of HL60 cells.
J Cell Biochem 80:471–482