Page 249 - Vitamin D and Cancer

236 C.M. Barnett and T.M. Beer

Peak concentrations NR NR NR 3.7–6.0 nM 1.4–3.5 nM 0.9–2.3 nM 6.68±1.42 ng/mL

Dose limiting toxicity Hypercalcemia Hypercalciuria Hypercalcemia Not determined Not determined Not determined Hypercalcemia

Companion drugs None None None None Paclitaxel 80 mg/m 2 weekly Zoledronate 4 mg IV monthly; dexamethosone 0.75 mg BID added at progression Gefitinib 250 mg daily

Schedule and route Daily/orally Daily/orally Every other day/ subcutaneous Weekly/orally Daily for 3 days every 7 days/orally Daily for 3 days every 7 days/orally Weekly/I.V.

Dose escalation studies of calcitriol in cancer Dose of calcitriol 0.5–1.5 mg 0.5–2.5 mg 2.0–10 mg 0.06–2.8 mg/kg 4–38 mg 4–30 mg 15–96 mg

Table 10.5 Investigator Osborn et al. (1995) [127] Gross et al. (1998) [128] Smith et al. (1999) [129] Beer (2001) [130] Muindi (2002) [131] Morris (2004) [136] Fakih (2007) [137] NR not reported