Page 353 - Vitamin D and Cancer

340 Index

D G
1,25D (calcitriol), 103–107, 298 Growth factor (GF), 17, 37, 56, 100–103, 152,
3
1,25(OH) D , 2–10, 12–17, 30, 130, 177–184, 156, 157, 159, 224, 252, 253, 283
2
3
193, 194, 196–201, 203, 205–209, 212, Growth factor receptor (GFR),
253–269, 316, 335 148, 152, 226
D . See Ergocalciferol
2
25D (25 hydroxyvitamin D), 282, 283, 286,
288, 289, 297 H
25(OH)D. See 25-Hydroxyvitamin D Heat shock protein (HSP), 29, 263
D binding protein (DBP), 26, 119, 196, 268, Hematopoiesis, 29, 155, 160, 162, 251–253,
286, 329–331 255–256, 258, 260, 261, 268
Differentiation, 2–7, 16, 29, 32–37, 41, Histone deacetylase (HDAC), 11, 13, 27, 28,
42, 55, 56, 74, 143–163, 177, 187, 31, 35, 36, 41, 197, 198, 264
199–201, 204–206, 212, 252–256, Histone deacetylase inhibitor
258–264, 268, 283–287, 289, 296, 305, (HDACi), 18
316, 318, 320 Human mammary epithelial (HME), 9, 285,
1,25-Dihydroxyvitamin D (1,25(OH) D ), 288, 289
3
2
3
2, 54, 122, 123, 193, 199–206, 329 Human osteocalcin (hOC), 81, 156
Dimethylbenzanthracene (DMBA), Human osteopontin (hOP), 156
180–182, 287 24-hydroxylase (24OHase), 2, 6, 104, 156,
Dosage interval, 322, 323 196, 223–225, 268, 297, 298, 318–320
Downstream regulatory element antagonist 25-Hydroxyvitamin D (25(OH)D), 36, 38,
modulator (DREAM), 29 74–76, 78–82, 84–92, 119–120, 193,
281–282, 298, 315–323, 329–335
E
Early growth response protein 1(EGR-1), 161 I
Early progenitor (EP), 57, 58, 162, 253 IGF binding protein-5 (IBP-5), 154
Endothelial cells, 11, 57–58, 100–104, 106, Inflammatory cytokines, 55, 61–64,
107, 122, 232, 285, 286 107, 130
Enzyme kinetics, 315–323 Inositol triphosphate (IP ), 153, 199, 205
3
Epidemiology, 73–92, 121, 184, 226–231, Insulin like growth factor 1 (IGF-1), 283
240, 295–304, 322 Insulin-like growth factor binding protein-3
Epidermal growth factor (EGF), 5, 106 (IGFBP-3), 36, 62, 151, 225, 232
Epidermal growth factor receptor Interleukin (IL), 61, 62, 102, 105–107, 130,
(EGFR), 5, 17, 36, 102, 147, 148, 150, 131, 151, 163, 225, 226, 252–256, 266
154, 225 International unit (IU), 32, 76, 79, 81, 84–87,
Ergocalciferol (D ), 76, 194, 195, 240, 256, 90, 117, 118, 120, 122, 123, 128–130,
2
257, 263, 265–267, 281, 299, 322, 323, 176–178, 180, 181, 183, 185–187, 211,
328–333, 335 282–283, 299, 304, 306–309, 328
Estrogen receptor (ER), 7, 8, 10, 14, 15, 150,
152, 283, 285, 287
Estrogens, 7–11, 34, 151, 152, 159, 283, 287 J
Expression of extrarenal vitamin D hydroxy- Jun N-terminal kinase (JNK), 61, 147, 150,
lases, 2 153, 154, 156–158, 207, 208, 263
Extracellular-signal regulated kinase (ERK),
147, 152, 153, 156, 158–162, 168,
197–199, 209, 259, 261–263 K
Keratinocyte growth factor (KGF), 283
Keratinocytes, 2, 29, 33, 34, 152–154, 194,
F 200, 205–207, 316
Farnesoid X-activated receptor (FXR), 42 Kinase suppressor of Ras-1 (KSR-1), 156,
Feedback control, 259, 318 157, 159, 259, 262
Flow cytometry (FC), 104, 155 Kruppel-like factor 4 (KLF-4), 153